Osteocalcin

Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.

Also Known As:

4-Carboxyglutamic Protein, Bone; Bone gamma-Carboxyglutamic Acid Protein; 4 Carboxyglutamic Protein, Bone; Bone 4-Carboxyglutamic Protein; Bone gamma Carboxyglutamic Acid Protein; Calcium Binding Protein, Vitamin K Dependent; Protein, Bone 4-Carboxyglutamic; Protein, Bone Gla; Vitamin K Dependent Bone Protein; Bone Gla Protein; Calcium-Binding Protein, Vitamin K-Dependent; Gla Protein, Bone; Vitamin K-Dependent Bone Protein; Osteocalcin (human reduced), 3- de- L- tyrosine- 4- de- L- glutamine- 5- de- L- tryptophan- 6- de- L- leucine- 9- L- serine- 12- L- serine- 19- L- threonine- 22- L- glutamine- 28- L- alanine- 33- L- serine- 35- L- glutamine- 36- L- tyrosine- 38- L- leucine- 39- L- lysine- 40- L- threonine- 43- L- lysine- 45- L- isoleucine- 48- L- isoleucine- 49- L- threonine- 49a- L- isoleucine-

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Calcium-Binding Proteins: 1333
      - Osteocalcin: 3311

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Disease

Drug/Important Bio-Agent (IBA)